Busulfan therapy in myeloid metaplasia.

Use of Testosterone and Busulfan in the Treatment of Myelofibrosis with Myeloid Metaplasia.

By RIcii nD T. Suxii .n, DAVID E. JENKINS, JR. #{176} AND RALPH L. ENGLE, JR. With the technical assistance of Cynthia Q. Fuller I HE ANEMIA of myelofibrosis with myeboid metaplasia is related to impaired or ineffective erythropoiesis sometimes accompanied by a shortened red blood cell life span.13 The effectiveness of testosterone in stimulating erythropoiesis in patients with myelofibrosis wi...

Busulfan in the treatment of chronic myelocytic leukemia. The effect of long term intermittent therapy.

Myeloablation and autologous peripheral blood stem cell rescue results in hematologic and clinical responses in patients with myeloid metaplasia with myelofibrosis.

Current therapeutic options for myeloid metaplasia with myelofibrosis (MMM) are limited. A pilot study was conducted of autologous peripheral blood stem cell (PBSC) collection in 27, followed by transplantation in 21 patients with MMM. The median age was 59 (range 45-75) years. PBSCs were mobilized at steady state (n = 2), after granulocyte colony-stimulating factor (G-CSF) alone (n = 17), or a...

Pulmonary toxicity recurring after a six week course of busulfan therapy and after subsequent therapy with uracil mustard.

A growing number of drugs, including a number of alkylating agents, have been implicated as the cause of pulmonary diseases. A patient with chronic myelogenous leukemia presented with typical cytology, biopsy, and roentgenologic findings of lung toxicity after only six weeks of therapy with busulfan. There was subsequent clearing. A similar roentgenologic change also occurred after administrati...

Thalidomide therapy in compensated and decompensated myelofibrosis with myeloid metaplasia.